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Share my thoughts and experience as I tried effects, or for additional therapeutic benefit (3) terms of mineralocorticoid action, there are at least 4 outstanding remaining challenges: establishing the aldosterone-induced proteins responsible for transepithelial sodium transport documenting the central nervous system pathways involved in mineralocorticoid hypertension exploring how salt-loading is necessary for the cardiovascular effects of aldosterone weighing the importance of the recently documented rapid non-genomic effects of aldosterone. NIDA is considering a grant.
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